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Evaluation of the Incidence of Leukopenia and Agranulocytosis in Patients Receiving Combined Clozapi

Leukopenia as a risk factor for osteonecrosis of the jaw in metastatic prostate cancer treated using

Leukopenia associated with long-term colchicine administration

Initially fewer bloodstream infections for allogeneic vs. autologous stem-cell transplants in neutro

Risperidone-induced leukopenia: a case report and brief review of literature

A prospective, multicentre survey on antifungal therapy in neutropenic paediatric haematology patien

Practical considerations on current guidelines for the management of non-neutropenic adult patients

A Population-Based Study of Bacterial Spectrum in Febrile Neutropenic Patients

Microbiological profile and nutritional quality of raw foods for neutropenic patients under hospital

Neutropenic patients and their infectious complications at a University Hospital

Risk of Serious Neutropenic Events in Cancer Patients Treated with Bevacizumab: A Meta-analysis

A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leuk

INTRAABDOMINAL ABSCESS RELATED FUNGAEMIA CAUSED BY RHODOTORULA GLUTINIS IN A NON-NEUTROPENIC CANCER

Tacrolimus: a forgotten agent in kidney transplant leukopenia Tacrolimus: agente esquecido na leucop

Antibiotic Rotation for Febrile Neutropenic Patients with Hematological Malignancies: Clinical Signi

Epidemiological profile and sensitivity pattern of isolates causing invasive fungal infection vs. co

Clinical experience of granulocyte transfusion in the management of neutropenic patients with haemat

Neutropenic enterocolitis after high-dose chemotherapy and autologous stem cell transplantation: inc

Invasive pulmonary aspergillosis in non-neutropenic patients with and without underlying disease: A

Clinical analysis of combination therapy for febrile neutropenic patients in childhood cancer

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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