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Development and validation of a risk model for identification of non-neutropenic, critically ill adu

Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro

Computed tomography features of Stenotrophomonas maltophilia pneumonia in patients with neutropenic

Inoculum Effects of Ceftobiprole, Daptomycin, Linezolid, and Vancomycin with Staphylococcus aureus a

There should be no ESKAPE for febrile neutropenic cancer patients: the dearth of effective antibacte

Bronchoscopy as an indicator of tracheobronchial fungal infection in non-neutropenic intensive-care

Neutropenic Enterocolitis, a Growing Concern in the Era of Widespread Use of Aggressive Chemotherapy

Recurrent Neutropenic Enterocolitis in a Pediatric Patient

Oral Antibiotics for Fever in Low-Risk Neutropenic Patients With Cancer: A Double-Blind, Randomized,

Mucormicose intestinal em doente neutropénico: uma doen?a a suspeitar

Escherichia coli and Klebsiella pneumoniae bacteremia in patients with neutropenic fever: factors as

Contemporary management of perianal conditions in febrile neutropenic patients

Pharmacokinetic and Pharmacodynamic Evaluation of P-873 versus Klebsiella pneumoniae in a Neutropeni

Experimental Evidence That Granulocyte Transfusions Are Efficacious in Treatment of Neutropenic Host

In Vivo Activities of Ceftolozane, a New Cephalosporin, with and without Tazobactam against Pseudomo

An Evaluation of the Association of Leukopenia and Severe Infection in Patients With Systemic Lupus

The incidence of invasive fungal infections in neutropenic patients with acute leukemia and myelodys

Evaluation of Predictors of Adverse Outcome in Febrile Neutropenic Episodes in Pediatric Oncology P

Pharmacoeconomics of empirical antifungal use in febrile neutropenic hematological malignancy and he

The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of us

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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