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Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infecti

Anemia and Leukopenia in a Long-Term Parenteral Nutrition Patient During a Shortage of Parenteral Tr

Early discharge and ambulatory care of low-risk patients with neutropenic fever in Australia

Intravascular catheter-related bloodstream infection caused by Abiotrophia defectiva in a neutropeni

Repeating blood cultures in neutropenic children with persistent fevers when the initial blood cultu

Randomized controlled trial comparing ciprofloxacin and cefepime in febrile neutropenic patients wit

Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukope

Pemetrexed-induced neutropenic enteritis and severe cutaneous hyperpigmentation in a patient with ma

Granulocyte transfusion therapy in paediatric patients with severe neutropenic infection

Catheter-related bloodstream infection by Lindnera fabianii in a neutropenic patient

Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the compariso

Retrospective assessment of secondary prophylaxis for invasive aspergillosis in neutropenic hematolo

Assessment of the significance of respiratory culture of Aspergillus in the non-neutropenic patient.

Treatment of invasive candidiasis in neutropenic patients: systematic review of randomized controlle

Infection in Neutropenic Patients with Cancer

Detection of a novel bunyavirus associated with fever, thrombocytopenia and leukopenia syndrome in H

Oral Exposure to Phytomonas serpens Attenuates Thrombocytopenia and Leukopenia during Acute Infectio

Ciprofloxacin prophylaxis in high risk neutropenic patients: effects on outcomes, antimicrobial ther

EPICO project. Development of educational recommendations using the DELPHI technique on invasive can

Septic Shock Caused by Klebsiella pneumoniae Carbapenemase-Producing Enterobacter gergoviae in a Neu

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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