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Invasive candidiasis in non-neutropenic adults. Guideline-based management in the intensive care uni

Daptomycin use in neutropenic patients with documented gram-positive infections

De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an

Mixed treatment comparison of prophylaxis against invasive fungal infections in neutropenic patients

Use of Healthy-Donor Granulocyte Transfusions to Treat Infections in Neutropenic Patients with Myelo

3 Tesla proton MRI for the diagnosis of pneumonia/lung infiltrates in neutropenic patients with acut

Empirical antibiotics targeting Gram-positive bacteria for the treatment of febrile neutropenic pati

ANTIFUNGAL AND ANTIHEPATOTOXIC EFFECTS OF SEPIA INK EXTRACT AGAINST OXIDATIVE STRESS AS A RISK FACTO

Measurements of procalcitonin facilitate targeting of endotoxin adsorption treatment in febrile neut

Donor Granulocyte Transfusions in Febrile Neutropenic Pediatric Oncology Patients

Positive Effects of Oral beta-Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Recei

Laparoscopic cholecystectomy for acalculous cholecystitis in a neutropenic patient after chemotherap

Diagnostic Value of the Serum Galactomannan and (1,3)-beta-D-glucan Assays for Invasive Pulmonary As

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients

How to manage aspergillosis in non-neutropenic intensive care unit patients

Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intrace

The Complication of Gastro-Enteric Fistulisation in Neutropenic Enterocolitis Secondary to Aplastic

Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case d

Replacement of Mycophenolate Acid With Everolimus in Patients Who Became Neutropenic After Renal Tra

Killing rates exerted by caspofungin in 50% serum and its correlation with in vivo efficacy in a neu

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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