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Pharmacodynamics of Cefquinome in a Neutropenic Mouse Thigh Model of Staphylococcus aureus Infection

Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases W

Leukopenia as a Biomarker of Sunitinib Outcome in Advanced Renal Cell Carcinoma

Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with

Efficacy of single large doses of caspofungin in a neutropenic murine model against the "psilosis" g

Economic Evaluation of Posaconazole Versus Fluconazole or Itraconazole in the Prevention of Invasive

Development and Validation of a Clinical Model to Predict the Presence of beta-Lactam Resistance in

Are Patients with Erythema Migrans Who Have Leukopenia and/or Thrombocytopenia Coinfected with Anapl

Use of procalcitonin and C-reactive protein as infection markers in febrile neutropenic patients und

Neutropenic Fever

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Management of acute colorectal diseases in febrile neutropenic patients

Predictors of mortality in non-neutropenic patients with invasive pulmonary aspergillosis: does gala

Significant Inconsistency Among Pediatric Oncologists in the Use of the Neutropenic Diet

Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality

Posaconazole prophylaxis in neutropenic patients with hematological malignancies: limits in clinica

In Vivo Activity of Cefquinome against Escherichia coli in the Thighs of Neutropenic Mice

Immunoproteomic to Analysis the Pathogenicity Factors in Leukopenia Caused by Klebsiella Pneumonia B

Bloodstream infections in neutropenic patients with cancer: Differences between patients with haemat

Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging fo

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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