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Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the par

Comparative Pharmacodynamics of Posaconazole in Neutropenic Murine Models of Invasive Pulmonary Aspe

Serum Antibody Signature Directed against Candida albicans Hsp90 and Enolase Detects Invasive Candid

Vancomycin Dosing in Neutropenic Patients

How to treat severe infections in critically ill neutropenic patients?

First Report of Westerdykella dispersa as a Cause of an Angioinvasive Fungal Infection in a Neutrope

Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic pat

Dental Extraction in the Neutropenic Patient

Incidence and Management of Leukopenia/Neutropenia in 233 Kidney Transplant Patients Following Singl

Leukocyte Count Restoration Under Dabrafenib Treatment in a Melanoma Patient With Vemurafenib-Induce

Diagnosis and antimicrobial therapy of lung infiltrates in febrile neutropenic patients (allogeneic

Leukopenia Predicts Remission in Patients with Inflammatory Bowel Disease and Behcet's Disease on Th

Cefozopran, meropenem, or imipenem-cilastatin compared with cefepime as empirical therapy in febrile

Risk Factors for Ganciclovir-Induced Thrombocytopenia and Leukopenia

In Vivo Pharmacokinetics and Pharmacodynamics of the Lantibiotic NAI-107 in a Neutropenic Murine Thi

The Novel Immunotherapeutic Oligodeoxynucleotide IMT504 Protects Neutropenic Animals from Fatal Pseu

Prognosis of neutropenic patients admitted to the intensive care unit

Development and Validation of a Prediction Model for Diagnosing Blood Stream Infections in Febrile,

Fluoroquinolone resistance in bacteremic and low risk febrile neutropenic patients with cancer

Once-daily, oral levofloxacin monotherapy for low-risk neutropenic fever in cancer patients: a pilot

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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