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關閉Antibiotic Use Before Chemotherapy: A Risk Factor for Developing Neutropenic Colitis in Children Wit
Febrile Neutropenic Infection Occurred in Cancer Patients Undergoing Autologous Peripheral Blood Ste
Epidemiology and outcome of bacteraemia in neutropenic patients in a single institution from 1991-20
Extended-Spectrum beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Bacteremia in
Human plasma cell-free DNA as a predictor of infectious complications of neutropenic fever in hemato
Pneumonia in the neutropenic cancer patient
Association between early peak temperature and mortality in neutropenic sepsis
Economic evaluation of a preemptive treatment strategy for invasive fungal infection in neutropenic
An update to the cost-effectiveness of posaconazole vs fluconazole or itraconazole in the prevention
Moxibustion for the treatment of chemotherapy-induced leukopenia: a systematic review of randomized
Invasive Aspergillosis in Neutropenic Patients During Hospital Renovation: Effectiveness of Mechanic
Immune reconstitution inflammatory syndrome in neutropenic patients with invasive pulmonary aspergil
Different clinical presentation of community-onset bacteremia among neutropenic adults in the ED
應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者：任蕾，秦貴軍，鄭麗麗，張會娟，孫良閣，段宇中華醫院感染學雜志 ２０１４年第２４卷第１７期
【摘要】目的 分析使用抗甲狀腺藥物（ＡＴＤ）引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析７２例使用ＡＴＤ引起粒細胞缺乏及引發感染患者的臨床資料，采用ＳＰＳＳ１１．０ 軟件進行統計分析。 結果 ７２例患者感染部位以呼吸道為主，占５５．３％，其次為泌尿系、胃腸道，分別占２１．１％ 和１０．５％；共分離出病原菌５２株，其中革蘭陽性菌２０株占３８．５％；革蘭陰性菌２６株占５０．０％；真菌６株占 １１．５％；革蘭陽性菌對萬古霉素和替考拉寧敏感性最高，分別為９０．０％和１００．０％，對其他抗菌藥物均存在不同 程度的耐藥性；革蘭陰性菌對美羅培南和亞胺培南敏感性最高，均為９２．３％，對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ＡＴＤ容易引起患者粒細胞缺乏，繼而誘發各種感染，且感染部位以呼吸道 最為常見，引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當，真菌感染相對較少。
【關鍵詞】抗甲狀腺藥物；粒細胞缺乏；感染
